Can Stress Affect Methylation?

What is Methylation?

Methylation is a relatively simple but most important biochemical process that continually proceeds in your entire body. Simply, Methylation is an activation process through which many potential molecules are activated, like; coenzymes, neurotransmitters, cysteine, glutathione, etc.

Methylation is the addition of the Methyl group on the chemicals or substances to activate them to perform their functions effectively. The methyl groups act as activators because their presence enables the respective chemicals to do their jobs actively. The methyl group (–CH3) is a small molecule containing one carbon and three hydrogen atoms attached to it. The reverse of Methylation is Demethylation (detachment of methyl group from chemicals); when the substances finish their functions, the methyl group detached from them.

Why is it important?

No doubt Methylation is an essential process of your body. Thinks for a second, if Methylation of your mood-regulating chemicals does not occur, such as; serotonin and dopamine. These neurotransmitters are responsible for your happiness; imagine if these chemicals do not activate, how you can feel pleasure. Similarly, if homocysteine’s Methylation does not occur; homocysteine-level rises, resulting in cardiovascular diseases.

This simple phenomenon, butworth more than a billion dollars. While the methylation cycle constantly continues, the various process helps regulate your hormones, repair DNA, boost the immune system, produce energy, repair damaged cells, maintain pregnancy, produce antioxidants, promote detoxification, reduce stress, improve mental health and many others more processes.

How does Stress affect DNA Methylation?

Stress shows prolonged effects on your body and contributes to mood and anxiety disorders. You have to make yourself happy; otherwise, it gradually diminishes you. Stress not only affects DNA methylation but also numbers of other processes. DNA methylation is epigenetic mechanisms. Epigenetics means small changes in DNA due to your environment and behavior that do not alter the sequence of your DNA. DNA methylation refer to the addition of a methyl group to DNA.

Research shows that Stress influences DNA methylation and causes many disorders. Stress induces alterations in DNA methylation, resulting in changes in the genome expression of physiological mechanisms that build your behavior, and dysregulation that is dangerous for your mental health. The accurate gene expression of DNA sequence play a key role in your brain’s mental condition, even though chronic stress may induce many major depressive disorders. Your lifestyle, diet also influences Methylation. However, many other factors affect DNA methylation, and struggles are continue to explore them.

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How to optimize Methylation?

The methylation process continues until you provide fuel means, a methyl group. The universal-donor of the methyl group is S-AdenosylMethionine (SAMe) in your body. The optimization of Methylation is crucial. SAMe gets methyl group from 5- methyltetrahydrofolate (folate) and vitamins. However, in the United States, 60% of people who carry gene mutations cannot transform folate into 5-MTHF.

You should include nutrients in your diet that are sources of methyl groups such as; methylfolate,  choline, vitamin B6, B9, B12, riboflavin, and magnesium, etc. Check out the Ana Maria Lajusticia platform if you want to prevent migraines, improve your overall health through magnesium.


Methylation is a phenomenon that activates various substances to perform their functions properly. Without methylation, your significant body functions can be stopped. Stress affects the changes in DNA methylation; consequently, many physiological disorders like anxiety may occur. Your lifestyle also influences methylation. Your body should contain a high level of methyl-carrying nutrients to continue the methylation cycle properly.

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